Dossier overview
3
research areas
3
references
3
handling notes
01
Mechanism of action
Khavinson-group research describes thymalin effects on T-lymphocyte differentiation and immunoendocrine signalling, particularly in the context of thymic involution during ageing. Mechanism interpretation outside the originating literature is limited.
02
Research applications
- Thymic-peptide and immunoendocrine ageing research
- Hematopoietic / T-cell differentiation research
- Pineal-thymus axis research
Evidence at a glance
What's behind this profile
3 citations · 2002–2020
- In vitro
- 1
- Review
- 2
Cell, tissue, or biochemical assays outside a living organism.
Narrative or systematic reviews; no primary data.
Publication years
- 02
- 03
- 04
- 05
- 06
- 07
- 08
- 09
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
Counts are derived from the cited studies below. A study covering both in vivo and in vitro work is counted by its primary model. Sample size is reported in 1 of 3 citations. Findings remain model-specific and are not extrapolated to therapeutic use.
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
Peptides and Ageing
2002
Khavinson VKh et al. · Neuro Endocrinology Letters
- Model
- Narrative review of tissue-specific peptide preparations including thymalin and epithalamin
- Sample
- Multiple studies (rats, mice, fruit flies, rhesus monkeys, humans)
Reviewed Khavinson-group experimental and clinical data describing geroprotective effects of tissue-specific peptide preparations across multiple species.
Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells
2020
Khavinson VK et al. · Bulletin of Experimental Biology and Medicine
- Model
- In vitro — human hematopoietic stem cell differentiation assays
- Sample
- Not reported in abstract
Thymalin was associated with reduced stem-cell markers and elevated CD28+ expression, framed as activation of T-lymphocyte differentiation in the system used.
Characteristics of the pineal gland and thymus relationship in aging
2011
Lin'kova NS et al. · Advances in Gerontology
- Model
- Narrative review of pineal-thymus axis research
- Sample
- N/A (review)
Reviewed pineal and thymic peptide preparations (epithalamin, thymalin) in the context of immunoendocrine ageing, with claims of greater geroprotective effects from pineal preparations.
Evidence caveats
- Thymalin is not FDA-approved or EMA-approved. Its registered status in the Russian Federation does not constitute approval elsewhere.
- The peer-reviewed evidence base is concentrated within the Khavinson research network. Independent replication outside this group is limited, and findings should be interpreted accordingly.
04
Storage and handling
Store under controlled laboratory conditions with batch and preparation details recorded.
- Research-only inventory; not for human use outside the Russian Federation registered indications.
- Maintain batch and supplier documentation.
- Verify supplier provenance carefully — thymalin sold outside registered channels is heterogeneous.