Dossier overview
3
research areas
2
references
3
handling notes
01
Mechanism of action
Cited work reports AED-associated changes in cell-renewal and gene-expression markers (IGF1, FOXO1, TERT, TNKS2, NFκB) in mesenchymal stem-cell aging cultures and in kidney organotypic models. identity remains uncharacterised.
02
Research applications
- Mesenchymal stem-cell aging gene-expression studies
- Kidney tissue organotypic cultures
- Cell-renewal pathway
Evidence at a glance
What's behind this profile
2 citations · 2015–2020
- In vitro
- 2
Cell, tissue, or biochemical assays outside a living organism.
Publication years
- 15
- 16
- 17
- 18
- 19
- 20
Counts are derived from the cited studies below. A study covering both in vivo and in vitro work is counted by its primary model. Sample size is reported in 0 of 2 citations. Findings remain model-specific and are not extrapolated to therapeutic use.
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides
2020
Ashapkin V, Khavinson V, Shilovsky G, Linkova N, Vanuyshin B · Molecular Biology Reports
- Model
- In vitro — human embryo bone-marrow mesenchymal stem cells (FetMSCs line) in passage and stationary aging models
- Sample
- Not reported in abstract
Reported AED (Cartalax), KED, and KE modulated IGF1, FOXO1, TERT, TNKS2, and NFκB in MSC aging cultures.
Peptide Regulation of Cells Renewal Processes in Kidney Tissue Cultures from Young and Old Animals
2015
Chalisova NI, Lin'kova NS, Nichik TE, Ryzhak AP, Dudkov AV, Ryzhak GA · Bulletin of Experimental Biology and Medicine
- Model
- In vitro — organotypic kidney tissue cultures from young and old rats
- Sample
- Not reported in abstract
Reported short peptides including AED (T-31) modulated cell-renewal markers in organotypic kidney cultures from young and old rats.
Evidence caveats
- No controlled human trials indexed on PubMed at time of writing.
- All cited primary evidence originates from the Khavinson research network in St Petersburg; independent replication is limited.
- Findings are model-specific (organotypic / cell-culture) and are not extrapolated to therapeutic use.
04
Storage and handling
Typically stored in a cool, dry environment under controlled laboratory conditions per supplier documentation.
- Use supplier documentation for batch-specific handling.
- Limit repeated cycles during research inventory handling.
- Document date and storage condition where applicable.