Dossier overview
4
research areas
3
references
3
handling notes
01
Mechanism of action
AHK binds Cu(II) at the histidine . work places the AHK and related DAHK in the same copper-handling family as GHK, with effects on osteogenic and antioxidant pathways in cell-culture research.
02
Research applications
- Cosmetic and hair-growth formulation research
- Copper-peptide comparative chemistry
- Osteogenic differentiation research
- Antioxidant copper-handling research
Evidence at a glance
What's behind this profile
3 citations · 2001–2021
- In vitro
- 3
Cell, tissue, or biochemical assays outside a living organism.
Publication years
- 01
- 02
- 03
- 04
- 05
- 06
- 07
- 08
- 09
- 10
- 11
- 12
- 13
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- 15
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- 19
- 20
- 21
Counts are derived from the cited studies below. A study covering both in vivo and in vitro work is counted by its primary model. Sample size is reported in 0 of 3 citations. Findings remain model-specific and are not extrapolated to therapeutic use.
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
Vitamin C-linker-conjugated tripeptide AHK stimulates BMP-2-induced osteogenic differentiation of mouse myoblast C2C12 cells
2018
Jung JI et al. · Differentiation
- Model
- In vitro — C2C12 mouse myoblast cells
- Sample
- N/A (cell culture)
Vitamin C-conjugated AHK was associated with enhanced osteoblast differentiation via Smad and pathway activation in the cell model used.
An analog of the human albumin N-terminus (Asp-Ala-His-Lys) prevents formation of copper-induced reactive oxygen species
2001
Bar-Or D et al. · Biochemical and Biophysical Research Communications
- Model
- In vitro antioxidant / copper-binding chemistry
- Sample
- N/A (biochemical assay)
Reported that the DAHK forms tight Cu(II) complexes that prevented copper-induced reactive oxygen species in the system used.
Binding Models of Copper(II) Thiosemicarbazone Complexes with Human Serum Albumin: A Speciation Study
2021
May NV et al. · Molecules
- Model
- In vitro spectroscopic copper-binding speciation study (incl. DAHK reference)
- Sample
- N/A (biochemical assay)
Demonstrated selective Cu(II) binding by the DAHK framework with affinity dependent on the bound complex charge.
Evidence caveats
- Primary peer-reviewed AHK / AHK-Cu literature is limited and overlaps with the related DAHK serum-albumin N-terminal sequence research.
- Cosmetic and hair-growth claims associated with AHK-Cu in commercial channels are not supported by the controlled-trial evidence base.
04
Storage and handling
Store under controlled laboratory conditions, protected from excess light and moisture, with batch and preparation details recorded.
- Protect from excess light and moisture during research storage.
- Maintain batch traceability for copper-complexed material.
- Research-only inventory; not for human use.