Dossier overview
3
research areas
2
references
3
handling notes
01
Mechanism of action
Cited work attributes Pinealon activity to short-peptide gene-regulatory effects in cerebellar neurons and pineal-derived cells. identity and have not been fully characterised in peer-reviewed literature outside the originating research network.
02
Research applications
- Cerebellar granule-cell viability
- Pineal-cell signalling-molecule expression studies
- Rodent prenatal hyperhomocysteinemia models
Evidence at a glance
What's behind this profile
2 citations · 2011–2012
- Animal
- 1
- In vitro
- 1
Studies in rodents or other animal models.
Cell, tissue, or biochemical assays outside a living organism.
Publication years
- 11
- 12
Counts are derived from the cited studies below. A study covering both in vivo and in vitro work is counted by its primary model. Sample size is reported in 0 of 2 citations. Findings remain model-specific and are not extrapolated to therapeutic use.
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes
2011
Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A · Rejuvenation Research
- Model
- In vitro — rat cerebellar granule cells, neutrophils, and PC12 pheochromocytoma cells
- Sample
- Not reported in abstract
Reported Pinealon was associated with reduced free-radical signal and altered viability metrics in cultured neurons and PC12 cells.
Pinealon protects the rat offspring from prenatal hyperhomocysteinemia
2012
Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V · International Journal of Clinical and Experimental Medicine
- Model
- In vivo — rat offspring exposed to prenatal hyperhomocysteinemia, with cerebellar neurons isolated from offspring
- Sample
- Not reported in abstract
Reported Pinealon administration reduced hyperhomocysteinemia-associated markers in rat offspring cerebellar tissue.
Evidence caveats
- No controlled human trials indexed on PubMed at time of writing.
- All cited primary evidence originates from the Khavinson research network in St Petersburg; independent replication is limited.
- Findings are model-specific (rodent / cell-culture) and are not extrapolated to therapeutic use.
04
Storage and handling
Typically stored in a cool, dry environment under controlled laboratory conditions per supplier documentation.
- Use supplier documentation for batch-specific handling.
- Limit repeated cycles during research inventory handling.
- Document date and storage condition where applicable.