Dossier overview
3
research areas
2
references
3
handling notes
01
Mechanism of action
SNAP-8 is proposed to compete with the SNAP-25 during SNARE-complex assembly, with the marketed claim being modulation of muscle-related expression in topical contexts. The molecular evidence base is limited, and clinical effect sizes in published cosmetic studies are small.
02
Research applications
- Topical cosmetic peptide formulation research
- Dermatology small-cohort wrinkle-depth assessments
- Microneedle and transdermal delivery studies
Evidence at a glance
What's behind this profile
2 citations · 2020–2024
- Human
- 2
Studies in human volunteers or patients (incl. early-phase trials).
Publication years
- 20
- 21
- 22
- 23
- 24
Counts are derived from the cited studies below. A study covering both in vivo and in vitro work is counted by its primary model. Sample size is reported in 0 of 2 citations. Findings remain model-specific and are not extrapolated to therapeutic use.
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
A clinical study on the efficacy and tolerability of an acetyl hexapeptide- and acetyl octapeptide-loaded dissolving microneedle patch on periorbital wrinkles
2020
Avcil M et al. · Journal of Cosmetic Dermatology
- Model
- Human pharmacology — small-cohort cosmetic study in adult volunteers
- Sample
- Not reported in abstract (small cohort)
Reported reduction in periorbital wrinkle metrics following topical microneedle delivery of acetyl hexapeptide and acetyl octapeptide-3.
Microneedle-mediated transdermal delivery of acetyl hexapeptide-8 and acetyl octapeptide-3 for periorbital wrinkles
2024
Shin J et al. · Annals of Dermatology
- Model
- Human pharmacology — small-cohort cosmetic study in adult volunteers
- Sample
- Not reported in abstract (small cohort)
Reported small but statistically reported improvements in periorbital wrinkle parameters with microneedle-delivered acetyl peptide combination.
Evidence caveats
- Cosmetic-trial evidence is limited to small cohorts and short follow-up.
- Mechanism is inferred from SNAP-25 sequence homology rather than direct SNARE-complex biochemistry in published peer-reviewed studies.
- Not a substitute for botulinum-toxin treatments; topical effect sizes in published studies are small.
04
Storage and handling
Typically stored in a cool, dry environment under controlled laboratory conditions per supplier documentation.
- Use supplier documentation for batch-specific handling.
- Limit repeated cycles during research inventory handling.
- Document date and storage condition where applicable.