Dossier overview
3
research areas
2
references
3
handling notes
01
Mechanism of action
FOX04-DRI is reported to compete with FOXO4 for binding to p53 in senescent cells, releasing p53 to the nucleus and triggering apoptosis selectively in cells with a senescence-associated FOXO4-p53 retention pattern. Activity outside senescent populations has been less characterised.
02
Research applications
- Senolytic mechanism studies
- Tissue-ageing and fibrosis rodent models
- Cell-culture senescence
Evidence at a glance
What's behind this profile
2 citations · 2020–2023
- Animal
- 2
Studies in rodents or other animal models.
Publication years
- 20
- 21
- 22
- 23
Counts are derived from the cited studies below. A study covering both in vivo and in vitro work is counted by its primary model. Sample size is reported in 0 of 2 citations. Findings remain model-specific and are not extrapolated to therapeutic use.
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
FOXO4-D-Retro-Inverso senolytic peptide attenuates pulmonary hypertension in a model of bleomycin-induced pulmonary fibrosis
2023
Born E et al. · Circulation
- Model
- In vivo — bleomycin mouse model of pulmonary fibrosis / pulmonary hypertension
- Sample
- Not reported in abstract
Reported FOX04-DRI attenuated pulmonary hypertension and senescence markers in a bleomycin-induced rodent fibrosis model.
FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice
2020
Zhang C et al. · Aging
- Model
- In vivo — aged C57BL/6 mice plus in vitro Leydig-cell senescence assays
- Sample
- Not reported in abstract
Observed clearance of senescent Leydig cells and partial restoration of testosterone secretion in aged male mice treated with FOXO4-DRI.
Evidence caveats
- No controlled human trials indexed on PubMed at time of writing.
- Findings are model-specific (rodent / in vitro) and are not extrapolated to therapeutic use.
- Senolytic off-target effects on non-senescent cells require further independent characterisation.
04
Storage and handling
Typically stored in a cool, dry environment under controlled laboratory conditions per supplier documentation.
- Use supplier documentation for batch-specific handling.
- Limit repeated cycles during research inventory handling.
- Document date and storage condition where applicable.