Dossier overview
3
research areas
3
references
3
handling notes
01
Mechanism of action
The MGF E-peptide is proposed to act independently of the mature IGF-1 pathway, with rodent and studies reporting effects on satellite-cell activation, proliferation, and protection of post-mitotic cells. Receptor identity and remain incompletely characterised.
02
Research applications
- Muscle satellite-cell activation studies
- Cartilage and articular repair rodent models
- Peripheral-neuropathy protection
Evidence at a glance
What's behind this profile
3 citations · 2010–2023
- In vitro
- 1
- Review
- 2
Cell, tissue, or biochemical assays outside a living organism.
Narrative or systematic reviews; no primary data.
Publication years
- 10
- 11
- 12
- 13
- 14
- 15
- 16
- 17
- 18
- 19
- 20
- 21
- 22
- 23
Counts are derived from the cited studies below. A study covering both in vivo and in vitro work is counted by its primary model. Sample size is reported in 0 of 3 citations. Findings remain model-specific and are not extrapolated to therapeutic use.
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
Research progress of mechano-growth factor in degenerative musculoskeletal diseases
2023
Liu R et al. · Regenerative Therapy
- Model
- Narrative review
- Sample
- N/A (review)
Reviews evidence for MGF E-peptide activity in cartilage and bone repair models and discusses -pathway uncertainties.
Mechano-growth factor E-peptide attenuates cisplatin-induced peripheral neuropathy
2020
Podratz JL et al. · Experimental Neurology
- Model
- In vitro — rat dorsal-root-ganglion neuron cultures
- Sample
- Not reported in abstract
Reported MGF E-peptide preserved DRG neurite outgrowth in cisplatin-exposed cultures.
Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration
2010
Matheny RW Jr, Nindl BC, Adamo ML · Endocrinology
- Model
- Mini-review
- Sample
- N/A (review)
Mini-review of the IGF-1Ec splice variant, the E-peptide it encodes, and reported effects in muscle and other tissues.
Evidence caveats
- No controlled human trials of synthetic MGF indexed on PubMed at time of writing.
- Receptor identity and downstream signalling for the isolated E-peptide are not fully characterised.
- WADA-prohibited under the S2 Peptide Hormones / Growth Factors category — relevant for athlete cohorts.
04
Storage and handling
Typically stored in a cool, dry environment under controlled laboratory conditions per supplier documentation.
- Use supplier documentation for batch-specific handling.
- Limit repeated cycles during research inventory handling.
- Document date and storage condition where applicable.