Dossier overview
4
research areas
3
references
3
handling notes
01
Mechanism of action
studies have associated AOD-9604 with increased fat oxidation and modulation of beta-3 adrenergic expression in mouse models. Mechanism in humans is not established in peer-reviewed clinical trial literature.
02
Research applications
- Rodent obesity and lipid metabolism research
- Beta-3 adrenergic pathway research
- Animal model osteoarthritis / cartilage research
- Anti-doping detection methodology
Evidence at a glance
What's behind this profile
3 citations · 2001–2015
- Animal
- 2
- In vitro
- 1
Studies in rodents or other animal models.
Cell, tissue, or biochemical assays outside a living organism.
Publication years
- 01
- 02
- 03
- 04
- 05
- 06
- 07
- 08
- 09
- 10
- 11
- 12
- 13
- 14
- 15
Counts are derived from the cited studies below. A study covering both in vivo and in vitro work is counted by its primary model. Sample size is reported in 1 of 3 citations. Findings remain model-specific and are not extrapolated to therapeutic use.
03
Study references
Each profile cites a minimum of two peer-reviewed sources, with model type and reported sample size where the source provides it. Findings are model-specific and must not be extrapolated to therapeutic use.
The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice
2001
Heffernan M et al. · Endocrinology
- Model
- In vivo — obese mice and beta-3 adrenergic receptor knockout mice (chronic treatment)
- Sample
- Not reported in abstract
Chronic AOD9604 administration was associated with reduced body weight and fat mass and altered beta-3 AR expression in obese mouse models.
Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model
2015
Kwon DR et al. · Annals of Clinical and Laboratory Science
- Model
- In vivo — New Zealand white rabbits (collagenase-induced osteoarthritis model)
- Sample
- n=32 rabbits
Intra-articular AOD9604 combined with hyaluronic acid was associated with greater cartilage-marker improvements and reduced lameness than either agent alone in the rabbit OA model used.
Detection and in vitro metabolism of AOD9604
2015
Cox HD et al. · Drug Testing and Analysis
- Model
- In vitro analytical study with metabolite identification in serum and urine matrices
- Sample
- Not reported in abstract
Reported a validated LC-MS detection method for AOD9604 with a 50 pg/mL limit of detection and identified a stable metabolite extending the detection window.
Evidence caveats
- AOD-9604 is not approved as a medicine. Phase IIa clinical research was reported in industry sources during 2002–2004, but full peer-reviewed clinical trial outcome papers in major databases are limited.
- Most primary efficacy data come from rodent models; extrapolation to clinical efficacy is not established.
04
Storage and handling
Store under controlled laboratory conditions with batch and preparation details recorded.
- Maintain batch traceability for and work.
- Record conditions and avoid repeated cycles.
- Research-only inventory must be clearly separated from approved therapeutic stocks.